bicosome (R)

Intelligent Skin Delivery Technologies


Bicosome is a start-up company that develops and commercialises high-performance cosmetic and dermo-pharmaceutical ingredients based on its patented proprietary platform: Bicosome® technology.

We have created an intelligent biological transporter with a breakthrough skin delivery mechanism that combines the most attractive properties of existing systems but far exceeds their capabilities.

Bicosomes resemble the skin’s natural biological structures. For this reason, they are able to naturally recognise the different skin environments and respond accordingly, delivering active ingredients where they are needed.

Scroll down to discover the potential of Bicosome® technology.

Last news

Come find us next month at in-cosmetics Global 2019! Stand W81

bicosome (R)


How it works

Bicosomes interact with the skin through an innovative biomimetic mechanism that imitates the skin's natural processes.

Each Bicosome® system is designed to reach specific areas of the skin, where the active ingredients are delivered.

When applied to the skin, the intelligent structures penetrate through the intercellular spaces until they reach their target layer.

Once there, in response to this environment, the bicosomes reassemble into bigger aggregates, releasing the active ingredients.

The bicosomes remain anchored in the skin, for long-lasting effects. Afterwards, the Bicosome® structures are integrated into the skin’s lipid matrix, strengthening the tissue. They are freed following the skin’s natural desquamation process.

The skin’s own biology is the driving force of the whole process.

Mechanism of Bicosome Penetration

Main benefits

Bicosome® is a highly versatile platform tailored to different molecules and to reach target skin layers. The double encapsulation and the innovative mechanism of penetration boost the performance of active ingredients and allow for creating highly innovative concepts.

Bicosome® platform:
  • Greater molecule stabilitys
  • Biomimetic mechanism
  • Target delivery
  • Long lasting effects
Bicosome® easy to use:
  • Encapsulation of hydrophilic and hydrophobic compounds
  • Compatible with a broad range of formulations
  • • Supplied with a complete technical pack
Bicosome® preserves nature:
  • Biocompatible and biodegradable
  • Clean production process
  • Vegan friendly
  • No animal testing


We will be pleased to clarify your doubts regarding Bicosome® Platform. Please fil the form and we will come back to you as soon as possible.

bicosome (R)


Skin penetration is one of the biggest challenges of topical treatments. This is because the main function of our skin is to act as a barrier to protect the body from external aggressions.

Most skin ingredients available on the market do not really penetrate the skin, acting only on the surface and disappearing after just a single wash. Other ingredients penetrate the skin aggressively, disrupting the skin barrier and causing damage. In both cases, efficacy and safety are compromised.

Bicosome® ingredients gently penetrate the skin to deliver active ingredients where needed and then integrate into the skin structure through a unique mechanism that boosts cosmetic treatments.

Proprietary Products

bicosome fs by bicosome

Bicosome® Filling up system is a biomimetic filler that delivers intelligent structures to help rebuild the skin’s architecture. Bicosome® FS enhances elasticity and firmness, reduces water loss and provides long-lasting effects for 7 days.

BICOTENE® Complex is a deep sun repair and protection system that stabilizes and delivers the Pro-Retinol in the epidermal layers, where they work repairing the damage caused by UV, IR, Vis & blue light radiations, neutralising the main causes of photoaging.

bicosome fs by bicosome

Bicowhite® Complex is a multi-target delivery system that blocks the main processes involved in the formation of dark spots. Bicowhite® whitens and brightens skin and specifically reduces melanin levels in hyper-pigmented areas, making it highly effective in evening out skin tone.

bicomide fs by bicosome

Bicomide® Sebum Control is a Bicosome system that targets the epidermis and follicles to effectively control sebum production and prevent the development of Acne. Bicomide® controls sebum production, prevents acne breakouts and reduces the irritation of acneic skin.

bicomide fs by bicosome

Bicohair® Anti Urban Pollution is an intelligent system created to protect the hair from urban pollution. Bicohair® UP adheres to the hair cuticle by electrostatic interactions working as shield protector that repeals pollution particles avoiding deposition, protects structural proteins from degradation caused by sun exposure and decreases the color loss caused by UV exposure and daily washings.

bicomide fs by bicosome

Bicohair® Heat Protection Is an intelligent system created to protect the hair against thermal damages. Bicohair® HP covers the hair fibre adding a barrier to the direct contact of the heat from tools or esthetic procedures. Additionally, its application recovers the hydration and mechanical properties of damaged hair.

Pipeline of Bicosome® Products


Bicosome® FS        
Bicohair® HP    
Bicohair® UP

Bicosome® systems are commercialised under a patent license agreement with the Spanish National Research Council (CSIC).


United States & Canada


Jeroen van den Bosch
T. (732) 224 0200 ext. 212
2 Bridge Avenue - The galleria Ste 631 Red Bank
NJ 07701 (EEUU)



Mariana Moreira 
+55 11 2974-7474 / +55 11 98487-1647 
Av. Angélica, 2220 - 9º Andar 
São Paulo SP 01228-200

Middle East & Africa


Raquel del Amo
T. (34) 667 793 103
Avenida de Séneca, 24 B5
San Sebastián de los Reyes (Spain)



Shail Vinayak
T. +91 1616 570 303 - 04
Village Mangarh, P.O.Kohara Chandigarh Road
Ludhiana 141112 (India)

United States


Kris Kudrnac
T. (1) 410 433 1517
300 Chestnut Ave, Suite 206
Baltimore, MD 21211 (EEUU)

United Kingdom


Daksha Patel
T. +44 (0) 7796 694327
Grote Markt 7
2000 Antwerp (Belgium)

France & Benelux


Anne-Marie Stevens
T. (06) 74 25 60 36
Grote Markt 7
2000 Antwerp (Belgium)



Irin Phuttisatien 
T. 02 683 5828 Ext 237
C/ Baldiri Reixac, 4 - 8, Torres R+D+I
08028 Barcelona (Spain)



Marco Colombo  

T. (0039) 3351351085
Via Mazzini, 33



Freek van Baars
T. +44 (0) 7796 694327
Grote Markt 7
2000 Antwerp (Belgium)



Deborah Kessler
T. (41) 44 396 99 33
Alte Landstrasse 105
8702 Zollikon (Switzerland)


Surfachem Polska

Aleksandra Rochowicz
T. (48) 739 245 966
The Embankment, Sovereign Street.
Leeds, LS1 4BA, UK

Spain & Portugal


Att. Rosana Saldaña
T. (34) 93 834 78 54
C/ Baldiri Reixac, 4 - 8, Torres R+D+I
08028 Barcelona (Spain)


We are willing to partner with cosmetic and pharmaceutical companies to explore the potential for new and challenging projects either with our proprietary line or exclusive developments.

Bicosome team frequently participate in the main scientific conferences and meetings around the world. Please contact us to meet in the upcoming events.


In-Cosmetics Global 2019/04 02-04 Paris
NYSCC Suppliers Day 2019/05 07-08 New York City
FCE Cosmetique 2019/05 21-23 São Paulo
Cosmetorium 2019/10 23-24 Barcelona
Sewapa Congress 2019/10 23-25 Berlin
In Cosmetics Asia 2019/11 05-07 Bangkok
5th Innovation Day 2019/11 Barcelona
SCS Formulate 2019/11 12-13 Coventry
bicosome (R)


Effective treatment for skin pathologies is still a challenge. A number of chronic diseases imply disruptions of skin structures, leading to uncomfortable and visible lesions that impacts not only on the physical health but also profoundly on patients’ quality of life.

Bicosome® Technology adds special value in these treatments. The composition and structure of Bicosomes mimic skin internal organisation . For this reason, aside from providing target delivery of the drugs encapsulated, the platform itself is capable of correcting defects in the skin matrix, improving of the skin condition and appearance. 

Different drugs such as antibiotics, anti-inflammatories, antifungal, vitamins, peptides and other kind of molecules have been incorporated in Bicosome® systems. The efficacy of the molecules is increased when carried by Bicosomes.

Our main target is the skin, but this delivery system can also be applied on other tissues such as the mucosa.

The way to market for Bicosome® Health Care products is through partnering and license agreements.

bicosome (R)

About us


Bicosome is a start-up company originated in the Institute of Advanced Chemistry of Catalonia (IQAC) part of the Spanish National Research Council (CSIC).

The company was founded in 2012 by a group of scientists specialised in the study of the skin tissue, in the biophysics of lipids, lipid structuration and surfactants.

As pioneers in this field of research, the founders of Bicosome have published in high impact journals and contributed to several conferences in international events. Their vision was to create a company to transform all this knowledge into real benefits that improve quality of life.

Bicosome® Technology is the result of three decades of serious scientific research focused on effective and safe skin penetration and targeted delivery.

Mission, Vision and Core Values


Our mission is to research, develop and commercialize highly innovative systems to deliver active ingredients into and through the skin.


In 2020 to be recognized as a global leading supplier of products based on delivery systems technologies for Dermo-Cosmetic Industry by providing customized solutions, earning trust and building lifetime relationships with our customers.

Core Values

Values are an important aspect of the Bicosome® team’s culture and constitute the common ground that unites the company. Our main values are the following:

  • Commitment to the highest quality research and excellence in innovation.
  • High standards of safety and reliability.
  • Confidentiality and integrity towards our customers.
  • Environmental consciousness.

Business Model

Bicosome business model is based on generating resources basically in two ways.

Commercialization of our own line of ingredients

Bicosome develops its own line of active ingredients based on the patented Bicosome® Technology.


Bicosome also develops exclusive and customized Bicosome® products for selected partners.

Financial Support

Bicosome has received financial support from Spanish funding institutions through NEOTEC, ENISA Young Entrepreneurs, INNCORPORA TU and TORRES QUEVEDO programs, supported by the Ministry of Economy and Competitiveness, co-funded by the European Social Fund.



Bicosome has also been granted with the “INNOVATIVE SME STAMP” by the Ministry of Economy and Competitiveness, co-funded by the European Social Fund.

European Projects

Bicosome has been granted with two projects funded by European Union programs.


Project Development, combination, formulation and encapsulation of bioactives from microalgae for skin care

This project has been funded by the European Union within the program Eurostars 2016. The Eurostars Programme is powered by EUREKA and the European Community



Project: Value Omega 3 and Astaxanthin products from Sea Algae.

This project has been funded by the European Union within the program "Horizon 2020 dedicated SME Instrument 2016-2017"


bicosome (R)

Contact us

Please describe your request.


T. (34) 93 834 78 54 

C/ Baldiri Reixac, 4 - 8, Torres R+D+I

Parc Científic de Barcelona

08028 Barcelona (Spain)