bicosome (R)


Bicosome is a start-up company that develops and commercializes high performance cosmetic and dermopharmaceutical ingredients based on a patented proprietary platform, the Bicosome® Technology.

Bicosome® Technology has a breakthrough mechanism for skin delivery, which combines the most attractive properties of existing lipid systems but far exceeds their capabilities and avoids their drawbacks.

In Bicosome® strategy both active ingredient and carrier work together in synergy to produce an outstanding result.

Keep scrolling down and discover the potential of Bicosome®.

Last news

The 2016 was a very special year for Bicosome with great achievements, straightforward partnerships, and where we took big steps towards our most ambitious dreams. The special Sunday edition of the Spanish journal "El Mundo" reflects very well the dynamic spirit of our company in the article entitled "Transporting molecules to the deepest layers of the skin". It is our pleasure to share it with you. See more at Transporting molecules to the deepest layers of the skin

 We wish you Merry Christmas and a wonderful 2017!

bicosome (R)


How it works

Bicosomes interact with the skin through an innovative biomimetic mechanism that respects the skin's natural processes. 

When applied on the skin, the smart structures of bicosomes are able to modulate the skin barrier function and penetrate the skin, carrying active ingredients into targeted layers.

Bicosomes can be designed to reach different deepness in the skin. Once in the target layer, they reorganize their structures and grow whilst remaining anchored  in between the skin cells, refilling our natural lipid matrix.

This effect allows for the active ingredients carried by the Bicosomes to be anchored in specific skin layers and to be slowly delivered.

Bicosomes per se have a natural capacity to regenerate skin lipid structures and to improve the barrier function and the elastic parameters of the skin.

Bicosomes remain anchored in the skin until they are freed following the skin's reewal process. The driving force is the skin biology itself.

Mechanism of Bicosome Penetration

Main benefits

Bicosome® is a highly versatile platform that can be designed to reach targeted layers of the skin, boosting the performance of the active ingredients.

Bicosome® encompasses the most attractive properties of existing lipid systems, such as liposomes and mixed micelles, but far exceeds their capabilities and avoids their drawbacks.

Bicosome® per se:
  • Restore skin barrier function avoiding dehydration.
  • Improve skin elastic parameters.
  • May act as an enhancer or retarder of skin penetration. Product-oriented platform.
Bicosome® as carrier:
  • High encapsulation efficiency for hydrophilic and hydrophobic compounds.
  • Protects active ingredients from degradation.
  • Compatible with emulsions, gels, serums and other skin vehicles.
Bicosome is green:
  • Biocompatible and biodegradable composition that supports preservation of nature and reduces harmful effects to the users.
  • Bicosomes do not contain surfactants.
  • Clean production process. No organic solvents involved.
  • Bicosome company does not perform animal testing.


We will be pleased to clarify your doubts regarding Bicosome® Platform. Please fil the form and we will come back to you as soon as possible.

bicosome (R)


Skin penetration is one of the biggest challenges for skin care formulators. This is because the main function of our skin is to be a barrier protecting the organism from external aggression. In order to penetrate the skin, the ingredient should be able to overcome the skin's barrier function.

Most skin ingredients available in the market do not really penetrate the skin, exerting their effects on the skin surface and disappearing after just a single wash. Other ingredients penetrate the skin aggressively, disrupting the skin barrier and causing damage. In both cases, efficacy and safety are compromised.

Bicosome® based ingredients are able to modulate skin barrier function without damaging the skin and to penetrate and reach the desired layer, where the active ingredients need to be delivered. Bicosomes get anchored in between skin layers promoting higher efficacy and long lasting benefits.

Proprietary Products

bicosome fs by bicosome

Bicosome® Filling up system (Bicosome® FS) is a biomimetic filler that delivers bilayer-forming structures in the intercellular spaces of the skin. This allows for the replenishment of the lipid matrix and the rebuilding of skin architecture. Bicosome® FS restores the barrier function and improves the elasticity and firmness of skin, helping to recover the skin equilibrium and smoothness. The Bicosome® FS benefits have a prolonged action of at least seven days.

Bicosome® Filling up system (Bicosome® FS) is a biomimetic filler that delivers smart bilayer-forming structures to reinforce and rebuild the skin.

Skin's natural lipid matrix is organized in lipid bilayers, which are responsible for the skin's barrier function. Several skin disorders are characterized by or originate from defects in the lipid bilayered arrangement of the skin. The conservation and reinforcement of the skin lipid architecture is vital for maintaining a healthy, smooth and equilibrated skin.

Bicosome® FS contains smart structures that penetrate the skin and refill the lipid intercellular spaces with bilayers ordered like the natural lipid matrix. This system mimics the biological activity of the basal epidermal layers, rebuilding the lipid organisation of the skin. This allows for lipid matrix replenishment, barrier function restoration, and improvement of skin elasticity and firmness. The Bicosome® FS benefits have a prolonged action of at least seven days.

* Representation of skin stratum corneum 


The use of Bicosome® FS is indicated in daily care for preserving the integrity of the skin structure and improving skin appearance, and in specific treatments for rebuilding the skin bilayered arrangement.

Bicosome® FS is specially recommended to restore the skin after environmental aggressions like exposure to the sun, wind and pollution, and after chemical or physical treatments, like peelings, lasers, some medical therapies, or any other situation where the skin barrier needs to be restored.

Examples of formulations with Bicosome® FS: skin repair lotions, anti-aging fillers, facial serums, BB creams, long-lasting moisturisers, lip repair balms, treatments for sensitive skin, make-up, etc.

Bicosome® FS is available in liquid and lyophilized forms.

Summary of Bicosome® FS benefits:

  • Replenishes the skin intercellular spaces.
  • Preserves and repairs the lipid matrix architecture.
  • Restores the skin barrier function.
  • Improves the skin elasticity and firmness.
  • Provides long lasting effects of 7 days.

Bicotene® Antiox / UV & IR Protection Complex is a deep sun repair system that stabilises and delivers carotene molecules deep in the epidermis, providing biological sun protection. The supply of carotenes by Bicotene® Antiox reinforces the skin's defence mechanism, reduces the formation of free radicals generated by UV, Vis and IR, protects and repairs cell DNA from UV damage and prevents the degradation of collagen induced by IR radiation.

Excessive exposure to sunlight leads to the formation of free radicals (FR), to damages in cell DNA and to the degradation of the skin's extracellular matrix proteins. These are the main causes of premature skin aging, as well as several skin diseases.

Since the use of sunscreens does not cover the protection at deeper layers of the skin, an extra supply of protective molecules, such as the carotenes, deep in the skin, is essential to maintain the skin defence mechanism and to reverse photoaging.

Carotenes have a powerful antioxidant action that helps the body to scavenge FR, limiting the sun damage to cell membranes, DNA and skin protein structures. However, the topical application of carotenes is limited due to the inherent instability of these molecules that, if not properly formulated, are quickly inactivated.

Bicotene® Antiox / UV & IR Protection Complex (Bicotene® Complex) is a deep sun repair system based on Bicosome® technology that stabilises and delivers carotene molecules deep in the epidermis, providing biological sun protection. 

Bicotene® Complex protects the carotenes and AO vitamins from degradation and works as a biological sun protector reinforcing the skin's defence mechanism against free radical formation and preventing the degradation of proteins that support the skin. 

The supply of carotenes by Bicotene® Antiox reinforces the skin's defence mechanism, reduces the formation of FR generated by UV, Vis and IR rays, protects and repairs cell DNA from UV damage and prevents the degradation of collagen induced by IR radiation.

Bicotene® Antiox is the perfect ingredient to complete the sun protection provided by sunscreens, but not only. The inclusion of Bicotene® Antiox in the daily skin care routine provides anti-aging benefits and protection over other sources of FR, such as pollution, smoking habits, stress, some medical therapies, etc.

Examples of formulations with Bicotene® Complex: Sunscreens and other pre and post sun formulations, anti-aging serums, BB creams, anti-pollution lotions, detox essences, lipsticks and make-up, etc.

Bicotene® Antiox is available in liquid and llyophilized forms.

Summary of Bicotene® benefits:

  • Stabilises carotene molecules
  • Penetrates and delivers carotenes deep in the epidermis
  • Provides UV, Vis and IR FR protection
  • Prevents the degradation of skin collagen induced by IR
  • Protects and repairs cell DNA form UV damage
  • Increases and completes the protection of sunscreens

bicosome fs by bicosome

Bicowhite® Complex is a brightening/lightening multi-target delivery system that works blocking the different processes involved in the hyperpigmentation of the skin. Bicowhite® incorporates five complementary whitening actives named Azeloglicine, Niacinamide, Alfa-Bisabolol, Vitamin C and Phytic Acid, which are driven by different Bicosome structures to their specific site of action in the skin in a highly integrated, complete and effective approach.

Increased melanin production gives rise to different hyperpigmentation disorders characterized by the appearance of dark spots in the skin.

The main strategies to decrease the melanin content in the skin include preventing its formation, diminishing its transport or accelerating its elimination, which are complex processes that occur in different skin layers.

There are several active ingredients addressing one or more of these strategies. The limitation of these treatments usually resides in their poor skin penetration, which compromises their efficacy.

Bicosome® is a double encapsulation technology formed by intelligent structures able to penetrate and to be retained in specific skin layers. This allows for a multi-target delivery of various active ingredients in appropriate levels of the skin, which provides real benefit in complex skin disorders, where several processes are occurring in different skin levels at the same time.

Bicowhite Complex is a brightening / lightening multi-target delivery system based on Bicosome® technology that works blocking the different processes involved in the hyperpigmentation of the skin.

Bicowhite Complex incorporates five complementary whitening actives named Azeloglicine that blocks melanin formation, Niacinamide that blocks melanin transfer, Alfa-Bisabolol that work on inflammatory processes, Vitamin C that prevents ROS production and Phytic acid that stimulates cell renewal. These actives are driven by Bicosomes to their specific site of action in the skin in a highly integrated and complete approach.

In vitro studies showed that Bicowhite complex presents higher whitening activity than Kojic acid without the damage caused by this active in the skin structure. Skin treated with Bicowhite Complex during 10 days presented a reduction of the melanin in 45% below basal levels, even when the skin was exposed to UV radiation. The in vivo studies with Bicowhite will be available soon.

Examples of formulations with Bicowhite Complex: whitening lotions, skin tone unifying emulsions, brightening creams and serums, lightening essences, age spots lighteners, lightening make-ups, etc.

Bicowhite Complex is available in liquid form.

Summary of Bicowhite Complex benefits:

  • Integrates the treatment of five complementary whitening actives.
  • Uses the innovative multi-target delivery approach.
  • Reduces melanin content without damaging the skin structure.
  • Provides whitening activity in skin even during UV exposure.

Pipeline of Bicosome® Products

Bicosome developments focus on the improvement of the performance of active ingredientes. Our pipeline is made up of six products in the following stage of development:

Bicosome® FS        
Bico C Pure          

Bicosome® systems are commercialised under a patent license agreement with the Spanish National Research Council (CSIC).


Spain & Portugal


Att. Claudia Verdés
T. (34) 93 494 87 30
Pau Claris 99-101, Esc 2,1º1ª
08009 Barcelona (Spain)



Att. Paolo Trevisan 

T. (39) 335 621 05 91
Via della Pacciarna 67
21050 Gorla Maggiore (Italy)


OMYA (Schweiz) AG

Att. Beatrice Haeusler
T. (41) 62 789 22 46
Baslerstrasse 42
CH-4665 Oftringen (Switzerland)



Att. Christiane Heimann
T. (49) 511 897 11 4009
Baumwall 3
20459 Hamburg (Germany)

United Kingdom

DKSH Great Britain Limited

Att. Annabel Atkinson
T. (44) 0208 879 55 00
Wellington House- 3rd Floor, 68 Wimbledon Hill Road
London SW19 7PA (United Kingdom)

France & Benelux


Att. Françoise Broze
T. (06) 74 25 60 36
Grote Markt 7
2000 Antwerp (Belgium)

United States


Att. Kris Kudrnac
T. (1) 410 433 1517
300 Chestnut Ave, Suite 206
Baltimore, MD 21211 (EEUU)



Att. Magdalini Katri
T. (30) 698 64 5779 
Vouliagmenis Ave. 591
Argyroupolis 16452, Athens (Greece)

Middle East & Africa


Att. Raquel del Amo
T. (34) 667 793 103
Avenida de Séneca, 24 B5
San Sebastián de los Reyes (Spain)


Since Bicosome® platform is able to encapsulate a large variety of molecules we are willing to partner with cosmetic and pharmaceutical companies in co-developments projects that allow us to explore the full potential of our technology.

Our goal is to develop exclusive and customized high performance ingredients that potentiate and optimize topical or transdermal application of cosmetic and dermopharmaceutical molecules proposed by third parties. We are also open to different types of development agreements.

Bicosome’s representatives frequently participate in major business and scientific conferences and meetings around the world. Please contact us at any of the upcoming events.

Cosmética forum 2017/03 01-02 Madrid, Spain
BIO Europe Spring 2017/03 20-22 Barcelona, Spain
In-Cosmetics London 2017/04 04-06 London, UK
Future in formulations 2017/05 16-17 Barcelona, Spain
FCE Cosmetique 2017/05 23-25 São Paulo, Brazil
BIO International Convention 2017/06 19-22 San Diego, USA
Gordon Research Conference 2017/08 13-18 New Hampshire, USA
In-Cosmetics Brazil 2017/09 20-21 São Paulo, Brazil
BIOSPAIN  2017/09 28-30 Bilbao, Spain
Cosmetorium 2017/10 03-04 Barcelona, Spain
Sepawa Congress 2017/10 18-20 Berlin, Germany
CHPI Worldwide 2017/10 14-26 Frankfurt, Germany
MEDICA 2017/11 13-16 Dusseldorf, Germany
SCS Formulate 2017/11 15-16 Ricoh Arena, Coventry
bicosome (R)


Effective treatment of the skin is still a challenge. A number of skin diseases are considered chronic and have no effective tratments. Bicosome® Technology is a versatile platform that can be applied in different skin disorders. The capacity for these systems to regenerate skin barrier function and to target specific skin layers is the key to succeed in the dermatology field.

The Bicosome® strategy, in which actives are driven to specific skin layers whereas the system per se refills our natural lipid matrix is unique. 

Different drugs such as anti-biotics, anti-inflammatories, anti-fugals, vitamins and peptides have been incorporated in Bicosome® systems. The efficacy of the molecules is increased when they are carried in bicosomes.

Our main target is the skin, but this delivery system can also be applied on other tissues such as the mucosa.

The way to market for Bicosome® Health Care products is through partnering with selected pharmaceutical companies.

bicosome (R)

About us


Bicosome is a spinoff company of the Institute of Advanced Chemistry of Catalonia (IQAC) part of the Spanish National Research Council (CSIC).

The company was founded in 2012 by scientists with world-leading experience in lipid structures’ research, surfactants systems and their interaction with the skin tissue. As pioneers in this field of research, the founders of Bicosome have published in important high impact journals and contributed to several conferences in international events. Their vision was to create a company that could transform all this knowledge into real benefits that changes people's quality of life.

Bicosome® Technology is the result of three decades of serious scientific research focusing on effective and safe skin penetration and targeted delivery.

Bicosome Company develops high performance skin care ingredients based on the patented Bicosome® Technology. The ingredients are commercialized mainly to the Dermocosmetic and Pharmaceutical industries.

Mission, Vision and Core Values


Our mission is to research, develop and commercialize highly innovative systems to deliver active ingredients into and through the skin.


In 2020 to be recognized as a global leading supplier of products based on delivery systems technologies for Dermo-Cosmetic Industry by providing customized solutions, earning trust and building lifetime relationships with our customers.

Core Values

Values are an important aspect of the Bicosome® team’s culture and constitute the common ground that unites the company. Our main values are the following:

  • Commitment to the highest quality research and excellence in innovation.
  • High standards of safety and reliability.
  • Confidentiality and integrity towards our customers.
  • Environmental consciousness.

Business Model

Bicosome business model is based on generating resources basically in two ways.

Commercialization of our own line of ingredients

Bicosome develops its own line of active ingredients based on the patented Bicosome® Technology.


Bicosome also develops exclusive and customized Bicosome® products for selected partners.

Financial Support

Bicosome has received financial support from the Spanish funding institutions CDTI and ENISA through the following participative loans: NEOTEC and ENISA Young Entrepreneurs.


Bicosome has also been granted with INNCORPORA TU and TORRES QUEVEDO contracts by the Ministry of Economy and Competitiveness, co-funded by the European Social Fund.



This project has been funded by the European Union within the program "Horizon 2020 dedicated SME Instrument 2016-2017"



This project has received funding from the Eurostars-2 joint programme with co-funding from the European Union Horizon 2020 research and innovation programme,


bicosome (R)

Contact us

Please describe your request.


T. (34) 93 400 61 00 ext: 2106

C/ Jordi Girona 18 - 26

08034 Barcelona (Spain)