bicosome (R)

Intelligent Skin Delivery Technologies


Bicosome is a start-up company that develops and commercialises high-performance cosmetic and dermo-pharmaceutical ingredients based on its patented proprietary platform: Bicosome® technology.

We have created an intelligent biological transporter with a breakthrough skin delivery mechanism that combines the most attractive properties of existing systems but far exceeds their capabilities.

Bicosomes resemble the skin’s natural biological structures. For this reason, they are able to naturally recognise the different skin environments and respond accordingly, delivering active ingredients where they are needed.

Scroll down to discover the potential of Bicosome® technology.

Last news

We thank our partners in US, K3 Corp and Ultra Chemical, for the warm reception, hard work and assertive mindset during our annual training at Ultra headquarters in NJ.

bicosome (R)


How it works

Bicosomes interact with the skin through an innovative biomimetic mechanism that imitates the skin's natural processes.

Each Bicosome® system is designed to reach specific areas of the skin, where the active ingredients are delivered.

When applied to the skin, the intelligent structures penetrate through the intercellular spaces until they reach their target layer.

Once there, in response to this environment, the bicosomes reassemble into bigger aggregates, releasing the active ingredients.

The bicosomes remain anchored in the skin, for long-lasting effects. Afterwards, the Bicosome® structures are integrated into the skin’s lipid matrix, strengthening the tissue. They are freed following the skin’s natural desquamation process.

The skin’s own biology is the driving force of the whole process.

Mechanism of Bicosome Penetration

Main benefits

Bicosome® is a highly versatile platform tailored to different molecules and to reach target skin layers. The double encapsulation and the innovative mechanism of penetration boost the performance of active ingredients and allow for creating highly innovative concepts.

Bicosome® platform:
  • Greater molecule stabilitys
  • Biomimetic mechanism
  • Target delivery
  • Long lasting effects
Bicosome® easy to use:
  • Encapsulation of hydrophilic and hydrophobic compounds
  • Compatible with a broad range of formulations
  • • Supplied with a complete technical pack
Bicosome® preserves nature:
  • Biocompatible and biodegradable
  • Clean production process
  • Vegan friendly
  • No animal testing


We will be pleased to clarify your doubts regarding Bicosome® Platform. Please fil the form and we will come back to you as soon as possible.

bicosome (R)


Skin penetration is one of the biggest challenges of topical treatments. This is because the main function of our skin is to act as a barrier to protect the body from external aggressions.

Most skin ingredients available on the market do not really penetrate the skin, acting only on the surface and disappearing after just a single wash. Other ingredients penetrate the skin aggressively, disrupting the skin barrier and causing damage. In both cases, efficacy and safety are compromised.

Bicosome® ingredients gently penetrate the skin to deliver active ingredients where needed and then integrate into the skin structure through a unique mechanism that boosts cosmetic treatments.

Proprietary Products

bicosome fs by bicosome


Bicosome® Filling up system is a biomimetic filler that delivers intelligent structures to help rebuild the skin’s architecture. Bicosome® FS enhances elasticity and firmness, reduces water loss and provides long-lasting effects for 7 days.

Bicotene® Antiox is a deep sun repair and protection system that boosts the skin’s defences, protects collagen and cell DNA, and neutralises UV, Vis and IR damage in deep layers of the skin, providing comprehensive biological sun protection.

bicosome fs by bicosome

Bicowhite® Complex is a multi-target delivery system that blocks the main processes involved in the formation of dark spots. Bicowhite® whitens and brightens skin and specifically reduces melanin levels in hyper-pigmented areas, making it highly effective in evening out skin tone.

bicomide fs by bicosome

Bicomide® Acne Control is a special Bicosome® combination that works to control the processes related to the appearance and persistence of acne. Bicomide® controls sebum production, prevents acne breakouts and reduces the irritation of acneic skin.

Pipeline of Bicosome® Products


Bicosome® FS        
Bico Calm
Bico C Pure          

Bicosome® systems are commercialised under a patent license agreement with the Spanish National Research Council (CSIC).


Spain & Portugal


Att. Rosana Saldaña
T. (34) 93 400 61 00 ext 2153
Jordi Girona 18
08034 Barcelona (Spain)



Mr. Marco Colombo  

T. (0039) 3351351085
Via Mazzini, 33
Via Mazzini, 33


OMYA (Schweiz) AG

Att. Beatrice Haeusler
T. (41) 62 789 22 46
Baslerstrasse 42
CH-4665 Oftringen (Switzerland)



Att. Rosana Saldaña
T. (34) 93 400 61 00 ext 2153
Jordi Girona 18
08034 Barcelona (Spain)

United Kingdom


Att. Rosana Saldaña
T. (34) 93 400 61 00 ext 2153
Jordi Girona 18
Barcelona (Spain)

France & Benelux


Att. Anne-Marie Stevens
T. (06) 74 25 60 36
Grote Markt 7
2000 Antwerp (Belgium)


Surfachem Polska

Surfachem Polska
T. (48) 739 245 966 
The Embankment, Sovereign Street.
Leeds, LS1 4BA, UK

United States


Att. Kris Kudrnac
T. (1) 410 433 1517
300 Chestnut Ave, Suite 206
Baltimore, MD 21211 (EEUU)



Att. Magdalini Katri
T. (30) 698 64 5779 
Vouliagmenis Ave. 591
Argyroupolis 16452, Athens (Greece)

Middle East & Africa


Att. Raquel del Amo
T. (34) 667 793 103
Avenida de Séneca, 24 B5
San Sebastián de los Reyes (Spain)



Att. Shail Vinayak
T. +91 1616 570 303 - 04
Village Mangarh, P.O.Kohara Chandigarh Road
Ludhiana 141112 (India)


We are willing to partner with cosmetic and pharmaceutical companies to explore the potential for new and challenging projects either with our proprietary line or exclusive developments.

Bicosome team frequently participate in the main scientific conferences and meetings around the world. Please contact us to meet in the upcoming events.


Cosmética forum 2017/03 01-02 Madrid, Spain
BIO Europe Spring 2017/03 20-22 Barcelona, Spain
In-Cosmetics London 2017/04 04-06 London, UK
Future in formulations 2017/05 16-17 Barcelona, Spain
FCE Cosmetique 2017/05 23-25 São Paulo, Brazil
BIO International Convention 2017/06 19-22 San Diego, USA
Gordon Research Conference 2017/08 13-18 New Hampshire, USA
In-Cosmetics Brazil 2017/09 20-21 São Paulo, Brazil
BIOSPAIN  2017/09 28-30 Bilbao, Spain
Cosmetorium 2017/10 03-04 Barcelona, Spain
Sepawa Congress 2017/10 18-20 Berlin, Germany
CHPI Worldwide 2017/10 14-26 Frankfurt, Germany
MEDICA 2017/11 13-16 Dusseldorf, Germany
SCS Formulate 2017/11 15-16 Ricoh Arena, Coventry
bicosome (R)


Effective treatment for skin pathologies is still a challenge. A number of chronic diseases imply disruptions of skin structures, leading to uncomfortable and visible lesions that impacts not only on the physical health but also profoundly on patients’ quality of life.

Bicosome® Technology adds special value in these treatments. The composition and structure of Bicosomes mimic skin internal organisation . For this reason, aside from providing target delivery of the drugs encapsulated, the platform itself is capable of correcting defects in the skin matrix, improving of the skin condition and appearance. 

Different drugs such as antibiotics, anti-inflammatories, antifungal, vitamins, peptides and other kind of molecules have been incorporated in Bicosome® systems. The efficacy of the molecules is increased when carried by Bicosomes.

Our main target is the skin, but this delivery system can also be applied on other tissues such as the mucosa.

The way to market for Bicosome® Health Care products is through partnering and license agreements.

bicosome (R)

About us


Bicosome is a start-up company originated in the Institute of Advanced Chemistry of Catalonia (IQAC) part of the Spanish National Research Council (CSIC).

The company was founded in 2012 by a group of scientists specialised in the study of the skin tissue, in the biophysics of lipids, lipid structuration and surfactants.

As pioneers in this field of research, the founders of Bicosome have published in high impact journals and contributed to several conferences in international events. Their vision was to create a company to transform all this knowledge into real benefits that improve quality of life.

Bicosome® Technology is the result of three decades of serious scientific research focused on effective and safe skin penetration and targeted delivery.

Mission, Vision and Core Values


Our mission is to research, develop and commercialize highly innovative systems to deliver active ingredients into and through the skin.


In 2020 to be recognized as a global leading supplier of products based on delivery systems technologies for Dermo-Cosmetic Industry by providing customized solutions, earning trust and building lifetime relationships with our customers.

Core Values

Values are an important aspect of the Bicosome® team’s culture and constitute the common ground that unites the company. Our main values are the following:

  • Commitment to the highest quality research and excellence in innovation.
  • High standards of safety and reliability.
  • Confidentiality and integrity towards our customers.
  • Environmental consciousness.

Business Model

Bicosome business model is based on generating resources basically in two ways.

Commercialization of our own line of ingredients

Bicosome develops its own line of active ingredients based on the patented Bicosome® Technology.


Bicosome also develops exclusive and customized Bicosome® products for selected partners.

Financial Support

Bicosome has received financial support from Spanish funding institutions through NEOTEC, ENISA Young Entrepreneurs, INNCORPORA TU and TORRES QUEVEDO programs, supported by the Ministry of Economy and Competitiveness, co-funded by the European Social Fund.



Bicosome has also been granted with the “INNOVATIVE SME STAMP” by the Ministry of Economy and Competitiveness, co-funded by the European Social Fund.

European Projects

Bicosome has been granted with two projects funded by European Union programs.


Project Development, combination, formulation and encapsulation of bioactives from microalgae for skin care

This project has been funded by the European Union within the program Eurostars 2016. The Eurostars Programme is powered by EUREKA and the European Community



Project: Value Omega 3 and Astaxanthin products from Sea Algae.

This project has been funded by the European Union within the program "Horizon 2020 dedicated SME Instrument 2016-2017"


bicosome (R)

Contact us

Please describe your request.


T. (34) 93 400 61 00 ext: 2106

C/ Jordi Girona 18 - 26

08034 Barcelona (Spain)